- Tracing Lewis & Clark's route along the Missouri River, exploring the American West
- Kayaking and boating in the National Recreation segment of the river
- Encountering native wildlife like bald eagles and river otters
- Fly fishing for monster brown trout, rainbow trout, and carp below Holter Dam and the Fort Peck Reservoir
- Learning about the American West's history and art at the Lewis and Clark Trail Interpretive Center and the C.M. Russell Museum
- Visiting Hell's Canyon National Recreation Area, Fort Clatsop, and Lemhi Pass on the Continental Divide
- Glamping along the Missouri River with all the necessary amenities
- Exploring charming towns like New Madrid and Chester
- Discovering Paducah's colorful history and Old South traditions
- Taking a tram to the top of Gateway Arch in St. Louis for breathtaking views of the Mississippi River
- Stepping back in time at the historic river towns of Hermann and St. Charles
- Savoring award-winning wines at the Les Bourgeois Vineyards
- Dancing the night away to live music aboard the Missouri River boat cruise