Top Mississippi River Luxury Nature Trips & Packages 2025/2026

Our 7 most popular Mississippi River Luxury Nature Trips & Packages trips. Compare tour itineraries from 3 tour companies. 0 reviews.

7 Trips match your criteria (1 - 7 shown)

Cumberland River Cruise
Save this trip to your favorites or other list
4.5/5 Excellent
39 reviews
River Cruise
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Flexible schedule

Highlights

  • Enjoy a warm welcome at the visitor’s center by tour guides who are eager to share their knowledge.
  • Visiting one the many fine museums, to participating in a hands-on creative workshop at a local art gallery.
  • Visit the studios and galleries of Paducah’s resident artists.
  • See the Sailor Man's likeness in the town's own six-foot-tall bronze metal statue.
  • Visit the Museum of Westward Expansion and discover the lives of the explorers, cowboys and Native Americans who helped forge our nation.

Themes

Cultural, Nature & Wildlife, National Parks

What travelers are saying

"The food and entertainment were exceptional! Such a professional staff providing top notch service! The entertainment was different each night throughout the entire trip. Also, the chef was a former Food Network Chopped Champion delivering a variety of delicious options, including desserts! Loved the cooking class for our day at sea! This is a new ship with beautiful cabins and common areas. There was plenty of space to meet with friends, enjoy happy hour and take in the fabulous views at every port! Every day the crew was helpful and positive providing details about excursions and ports. There was so much to see and a welcome ship to come back to share each day's experience."

Trip dates & details
Save this trip to your favorites or other list
More
Upper Mississippi River Cruise
Save this trip to your favorites or other list
4.5/5 Excellent
39 reviews
River Cruise
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Flexible schedule

Highlights

  • Visit the Museum of Westward Expansion
  • Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum.
  • See the historic stables built in 1885 and the world-famous Clydesdale horses.
  • Visit the Interpretive Center, home to 15 original Normal Rockwell paintings, the Becky Hatcher House, the Huck Finn Home
  • Visit the national Mississippi River Museum and Aquarium.

Themes

Cultural, Nature & Wildlife, National Parks

What travelers are saying

"The food and entertainment were exceptional! Such a professional staff providing top notch service! The entertainment was different each night throughout the entire trip. Also, the chef was a former Food Network Chopped Champion delivering a variety of delicious options, including desserts! Loved the cooking class for our day at sea! This is a new ship with beautiful cabins and common areas. There was plenty of space to meet with friends, enjoy happy hour and take in the fabulous views at every port! Every day the crew was helpful and positive providing details about excursions and ports. There was so much to see and a welcome ship to come back to share each day's experience."

Trip dates & details
Save this trip to your favorites or other list
More
Complete Mississippi River Cruise
Save this trip to your favorites or other list
4.5/5 Excellent
39 reviews
River Cruise
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Flexible schedule

Highlights

  • Visit the picturesque Sydney and Walda Besthoff Sculpture Garden, one of the premier sculpture installations in the United States.
  • Enjoy a grand tour of one of the most historic cities in the South.
  • Enjoy a relaxing trip through the historic sites of the largest city in Mississippi including Cotton Row, the Mount Holly Plantation and the Weatherbee House.
  • Visit iconic sites such as the National Civil Rights Museum
  • Exploring this historic site,
Show more

Themes

Cultural, Nature & Wildlife, National Parks

What travelers are saying

"The food and entertainment were exceptional! Such a professional staff providing top notch service! The entertainment was different each night throughout the entire trip. Also, the chef was a former Food Network Chopped Champion delivering a variety of delicious options, including desserts! Loved the cooking class for our day at sea! This is a new ship with beautiful cabins and common areas. There was plenty of space to meet with friends, enjoy happy hour and take in the fabulous views at every port! Every day the crew was helpful and positive providing details about excursions and ports. There was so much to see and a welcome ship to come back to share each day's experience."

Trip dates & details
Save this trip to your favorites or other list
More

Want a tailor-made trip instead?

Your trip, your way, planned by an expert:

  • You choose budget, destinations, activities, transport & lodging type
  • Expert designs the itinerary for you, and once approved, takes care of logistics
Design custom trip
Soul of the Mississippi
Save this trip to your favorites or other list
3.7/5 Great
50 reviews
Small Ship Cruise
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Flexible schedule

Highlights

  • Discover Memphis
  • See one of the oldest Protestant churches in Louisiana
  • Explore New Orleans
  • Visit Oak Alley Plantation and St. Francisville

Themes

Cultural, Nature & Wildlife, National Parks, Small Ship Cruise

What travelers are saying

"Amazing tours,prepared and extremely helpful guides. Great experience overall.Highly recommended."

Trip dates & details
Save this trip to your favorites or other list
More
Cross-Country Highlights of America—The BIG Tour
Save this trip to your favorites or other list
5/5 Excellent
7 reviews
Group Tour
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Balanced schedule

Highlights

  • Visit San Francisco’s Fisherman’s Wharf, Nob Hill, Golden Gate Bridge, Hearst Castle, Sausalito, Oklahoma City Memorial
  • Enjoy picturesque “17-Mile Drive”
  • Visit Hollywood—Graumann’s Chinese Theatre, Hollywood Bowl
  • Visit Monterey, Rodeo Drive, glamorous Santa Barbara, Sacramento’s ”Old Town”
  • Experience Spectacular Rockies & Sierra Nevada Mountains, Mormon Tabernacle, Hoover Dam, Old Town Albuquerque, incomparable Grand Canyon National Park
Show more

Themes

Cultural, Nature & Wildlife, 50 Plus, National Parks, Transformative

What travelers are saying

"Would just like to thank Starr, Penny and our driver Chick for a great trip to Cape Cod this past weekend. Was the first time for my mom and I on an overnight trip, and everything worked out great. Thank you!"

Trip dates & details
Save this trip to your favorites or other list
More
Yellowstone & Western Treasures Cross-Country
Save this trip to your favorites or other list
5/5 Excellent
7 reviews
Group Tour
Lodging level
Premium - 4 star
Physical level
Very Easy
Trip pace
Balanced schedule

Highlights

  • Explore Majestic Yellowstone National Park, Old Faithful, Mt. Rushmore, Crazy horse Monument, & more.
  • Wild West casino excitement in Deadwood SD, an entire town designated a National Historic Landmark.
  • View the spectacular Big Horn Mountains, long considered sacred by the Sioux, Crow, & Cheyenne Indians
  • View the inspiring Grand Tetons & Rocky Mountain wilderness
  • Experience South Dakota’s ruggedly beautiful Badlands National Park, 242,000 acres of eroded pinnacles & spires blended with the largest undisturbed grass prairie in the US.
Show more

Themes

Cultural, Nature & Wildlife, 50 Plus, National Parks

What travelers are saying

"Would just like to thank Starr, Penny and our driver Chick for a great trip to Cape Cod this past weekend. Was the first time for my mom and I on an overnight trip, and everything worked out great. Thank you!"

Trip dates & details
Save this trip to your favorites or other list
More
New Orleans Southern Hospitality
Save this trip to your favorites or other list
5/5 Excellent
7 reviews
Group Tour
Lodging level
Premium - 4 star
Physical level
Easy
Trip pace
Balanced schedule

Highlights

  • Experience New Orleans by day and by night, on a driving city tour aboard your deluxe motorcoach with your own local guide, plus and evening Bourbon St. stroll
  • Unforgettable live jazz entertainment and signature New Orleans cocktails - including the (in)famous Hurricane at Pat O'Brien's!
  • Enjoy 4 nights at in the heart of downtown New Orleans, just steps from the shops, jazz, and fun of the French Quarter, the lucky action of Harrah’s Casino, and the excitement of Magazine Street. Your charming hotel artfully blends old world charm with modern comforts— premium pillow-top beds, coffee makers, laundry facilities, lobby cocktail lounge, spa, and pool.
  • Plenty of leisure time to explore the many sights, tastes, and sounds of the French Quarter

Themes

Cultural, Nature & Wildlife, 50 Plus, National Parks, Transformative

What travelers are saying

"Would just like to thank Starr, Penny and our driver Chick for a great trip to Cape Cod this past weekend. Was the first time for my mom and I on an overnight trip, and everything worked out great. Thank you!"

Trip dates & details
Save this trip to your favorites or other list
More
Sign in to reveal savings up to $700 per person!